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Response to Cochrane editors: A small number of studies were missed due to the primary focus on peer-reviewed reports in scientific journals. Google sheet here for the analysis of these articles: However, as of 14 Septemberthe Cochrane review itself had not yet included the additional data .
The analysis of trial eligibility is made difficult by the trial identifiers in the Cochrane HPV Review. Using the trial registry number as the main identifier could improve trial verification across multiple sources. Analysis of trial eligibility and comparisons are further hindered by discrepancies across multiple sources of trial information.
The trial registry has participants enrolled and who started vaccination and were analysed completed. NCT The trial study Pedersen et al. In the trial study Pedersen et al. As a result of our investigations, we believe that five eligible completed studies with available data representing 5, women may have been missed from the Cochrane Review.
The following correction is required: We consider this to be a matter of opinion, and that, therefore, there is no requirement for a correction or clarification. We recommend that authors of Cochrane reviews make every effort to identify all trials and their limitations and conduct reviews accordingly.
We found vs serious adverse events when we summarised the data from ClinicalTrials. Therefore, all included trials were funded by the HPV vaccine manufacturers. We consider it is reasonable to accept that GSK provided funding, at least in kind, since it provided vaccines and provided support related to the regulatory submission.
World Health Organization; Cancer Screening in the European Union Report on the implementation of the Council Recommendation on cancer screening. Health and Food Safety. No correction or clarification required.
However, what constitutes a COI in the context of Cochrane reviews should be open to further debate. We welcome feedback on the complex issues outlined in this report, particularly where there are areas of disagreement with our analysis, or where there are disagreements with our conclusions, or there are errors that require further changes.
COIs CH has co-authored 16 peer-reviewed articles with Tom Jefferson two of which are Cochrane reviews and holds grant funding jointly with Tom Jefferson from Cochrane on methods for deciding when to prioritise the use of clinical study reports in systematic reviews.PRISMA flowchart that shows the step-by-step process of the application of inclusion and exclusion criteria to generate a final number of studies .
A systematic review answers a defined research question by collecting and summarising all empirical evidence that fits pre-specified eligibility criteria. A meta-analysis is the use of statistical methods to summarise the results of these studies.
Writing a good discussion is probably the most challenging part of writing a good systematic literature review and this is often the part that ultimately decides if it is going to be published and read.
On 27 July , BMJ EBM published an analysis  that outlined problems with Cochrane’s systematic review of human papillomavirus (HPV) vaccine, which we shall refer to as the Cochrane HPV Review, published in May ; this included missing eligible trials, reporting bias, and biased trial designs and conflicts of interest.
Help with Writing a Systematic Review Writing a systematic review for your thesis or dissertation proposal takes time because of the amount of research that you must do beforehand in preparing the literature and studies on 5/5.
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